Self-care is a lifelong journey that is crucial to maintaining an optimal mind-body balance. But as anyone who has tried to prioritize self-care can attest, finding that balance can be elusive. That’s because for all the wellness fads that promise inner peace, the science to back up most of these trends is surprisingly slim.

Here’s what we know for sure: deep breathing can help calm the nervous system if you’re experiencing occasional anxiousness, a good night’s sleep and staying hydrated are essential in keeping the brain’s neurons firing on all cylinders, and daily movement releases feel-good endorphins that help promote positive vibes.

But if you want to target everyday stress and manage your mood for ultimate zen, science says we may be overlooking one aspect of health where balance matters most.

The Missing Link to Mind-Body Balance: The Gut-Brain Axis

The vagus nerve, also known as the gut-brain axis, which links the central and enteric nervous systems.

If you’ve been practicing daily self-care but still feel in a rut, emerging science indicates it could be your gut. That’s because your gut and brain are linked via the gut-brain axis. In fact, the gut is sometimes referred to as the body’s “second brain.” But a more appropriate description is the body’s “second nervous system.”

The brain’s nervous system — the one most people are familiar with — is called the central nervous system. The gut’s nervous system is called the enteric nervous system (this system even creates its own neurotransmitter dopamine). And the gut-brain axis through which they’re linked is an actual nerve called the vagus nerve. The vagus nerve is responsible for regulating several crucial bodily functions, like immune health, inflammatory response, digestion, heart rate, breath — and even mood.

In fact, one of the primary functions of the vagus nerve is to help calm the body down after acute, occasional stress.

The wildest part? Although the brain sends signals to the vagus nerve and the gut, the majority of the communication happening along the gut-brain axis goes the other way — from the gut to the brain. More specifically, many of these signals are made by microorganisms that populate the gut lining: your microbiome.[1]

What’s a Microbiome? And What Does It Have to Do With My Mood?

Everybody has a unique microbiome — an estimated 38 trillion microorganisms comprised of over 10,000 strains of bacteria, the majority of which live in your gut.

Your microbiome outnumbers your human cells 10:1, so it’s more you than you are! In fact, we can’t really talk about mind-body balance without talking about microbiome balance. And how do you achieve this balance? You can start by feeding the bacteria that make up your microbiome the nutrients they need to survive and thrive — and in turn, they’ll help support your mood, brain and cognitive health via the gut-brain axis.

Modere Axis™ Mental Uplift Collection: Better Mood Through Better Nutrition

Modere Axis Mental Uplift Collection on a blue background

While most of us aim to eat healthy, everyday stressors can make it difficult to prioritize nutrition. Whether you’re working late to meet a deadline, it’s your week for school pick-up or your mother-in-law drops by unannounced, there are no shortage of surprises to upend even the best-intentioned meal plan. What’s more, it can be tricky to know which foods to eat to support your mood.

Cue the Modere Axis Mental Uplift Collection.

Featuring 4 synergistic supplements formulated with research-recommended biotics, vitamins, minerals, adaptogens, antioxidants and phytonutrients, this collection elevates your daily self-care routine to help you maintain balance where it matters most. Not only do all 4 of these supplements support a solid nutritional foundation, but they also deliver targeted ingredients shown to:

  • Help reduce occasional stress*
  • Help reduce occasional anxiousness*
  • Help reduce oxidative stress*
  • Promote feelings of calm*
  • Promote balanced mood + energy*
  • Support brain + cognitive health*
  • Support mind + body wellbeing*

Let’s break down what’s inside!

Modere Axis™ TreBiotic

With the First Ever 3-in-1 Microbiome Matrix™

Modere Axis TreBiotic on a blue background.

If you think biotics are only for gut health, think again. This perfectly paired matrix of prebiotics, probiotics and postbiotics delivers unique microbiome support to benefit the gut, brain and more, with delicious chocolate flavored beadlets in a convenient, on-the-go stick pack.

How it biohacks your mood:

Axis TreBiotic is formulated with an exclusive blend of bacteria called NeuroFlora™ Probiotic Complex — 3 strains of bacteria not found in most biotic formulas. Not only do these highly researched strains of bacteria deliver the gut health benefits you expect from a probiotic, but may also support mood, energy and brain health.*

To help support the benefits of NeuroFlora Probiotic Complex, Axis TreBiotic includes GOS prebiotic, shown in vitro to help bacteria in NeuroFlora populate the gut faster, and with greater density. Our biotic formula also includes one-of-a-kind EpiCor® GI+ postbiotic, backed by 15 scientific studies and shown to help reinforce the gut lining for optimal nutrient absorption and microbiome health.*

Modere Axis™ Uplift

1 Plant-Based Formula. 2 Types of Stress Support.

Modere Axis Uplift on a blue background.

Formulated with plant-based adaptogens and antioxidant supporting ingredients, this 2-in-1 formula helps reduce occasional stress and anxiousness and helps reduce oxidative stress from free radicals.*

How it biohacks your mood:

Axis Uplift delivers 3 types of adaptogens: ashwagandha, schisandra and American ginseng, studied for their ability to help your body adapt to everyday stress. If you’re experiencing occasional anxiousness, adaptogens can help you feel calm. If you’re experiencing brain fog, adaptogens can help you feel energized and focused.*

Regardless of your mood, adaptogens help support a state of mind-body balance and promote resilience against everyday stress.*

Modere Axis™ Multivitamin

More Than Your Average Multivitamin

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Optimize daily nutrition critical to wellness with 22 premium vitamins and minerals in this highly bioavailable multivitamin. Axis Multivitamin provides over 100% DV of key nutrients your body needs to support brain and cognitive health, and to support other major body systems.*

How it biohacks your mood:

In addition to everyday nutrients your body needs to survive, like vitamins A, C, E and several key minerals, Axis Multivitamin is an excellent source of B complex vitamins, which illuminate the path of neurotransmitter synthesis and are essential to nervous system and brain health.*

Axis Multivitamin also provides minerals like selenium and magnesium known to help support mood, energy levels and cognitive function, and promote a normal, healthy stress response.*

Modere Axis™ PhytoReds

10 of the World’s Most Powerful Red Phytonutrients

Modere Axis Phytoreds on a blue background.

Anyone who’s tried to meet their daily intake of fresh fruits and vegetables knows how difficult it can be, but with highly bioavailable and bioactive red fruits and vegetables in Axis PhytoReds, you can still obtain potent phytonutrient benefits in each delicious scoop.

How it biohacks your mood:

Phytonutrients have a synergistic relationship with pre-, pro- and postbiotics when it comes to supporting a balanced microbiome. The gut may benefit from phytonutrients to support a diverse population of bacteria, which in turn, helps reinforce a healthy gut lining, which helps optimize the absorption of phytonutrients.

In addition, the 10 phytonutrient-rich red fruits and vegetables in Axis PhytoReds are shown to support vitality, antioxidant capacity and immune health, which all play a role in facilitating a healthy, normal stress response.*

Take 4, Try 4: A Holistic, Science-Backed Approach to Self-Care

The Modere Axis Mental Uplift Collection isn’t meant to replace your current self-care routine — it enhances it. For optimal results, we recommend pairing its 4 formulas with 4 daily activities widely recognized for their benefits on mood: movement, breathing exercises, hydration and journaling.

The formula is simple: Take 4 supplements, Try 4 daily activities. Here’s how each benefits your mood:

Daily Movement

Exercise stimulates the release of endorphins, the body’s natural mood enhancers. Regular physical activity also improves sleep quality, contributing to mind-body balance. And although an exercise regimen is doctor-recommended for a variety of health reasons, daily movement for better mood can be as simple as stretching at your desk, taking a nature walk or dancing to your favorite song.

Breathing Exercises

Mindful breath work supports the vagus nerve, promoting relaxation and helping to reduce occasional stress. Techniques like diaphragm breathing can be integrated into daily routines like yoga or meditation — you can even do it in the shower! To learn how to do this breathing technique, and for more breathing exercises to try like box breathing and pursed-lip breathing, head to the Take 4, Try 4 section at


Dehydration can impair cognitive function and mood, so it follows that staying well-hydrated supports overall health and mental clarity. But how much water do you need daily? While 8 glasses of water is the traditional advice, most health experts agree that you should aim for quite a bit more: 15 cups (120 fl oz.) daily for men and 11 cups (90 fl oz.) daily for women. If you’ve been looking for an excuse to buy that cute water bottle you’ve been eyeing, this is it! 


Expressive writing serves as a therapeutic outlet for your thoughts, aiding in processing and managing your emotions. There are no rules about what you can or cannot write about, but many people find that keeping a gratitude journal positively impacts mood by shifting focus from everyday stressors to the abundance and joy in your life, fostering a sense of peace and contentment.

The science of stress is complex, but how you cope with everyday stress and occasional anxiousness doesn’t have to be complicated! With Modere Axis Mental Uplift Collection and the Take 4, Try 4 method, you have a holistic toolkit at your disposal to biohack your mood in an effective, science-backed way for mind-body balance that helps you feel like your best self every day.

*This statement has not been evaluated by the Food and Drug Association. These products are not intended to diagnose, treat, cure or prevent any disease.